MafB negatively regulates RANKL-mediated osteoclast differentiation (Short title: The negative role of MafB in osteoclastogenesis)
نویسندگان
چکیده
To whom correspondence should be addressed: Nacksung Kim, Ph.D. Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak-Dong 5, Dong-Ku, Gwangju 501-746, Korea. Phone: 82-62-220-4418, Fax: 82-62-223-4018, E-mail: [email protected] Contribution K.Kim, J.H.Kim, J.Lee, and H.M.Jin : performed research and analyzed data H.Kook : contributed vital reagents K.K.Kim : contributed vital analytic tools S.Y.Lee : contributed vital reagents and analytic tools N.Kim : designed research and wrote the paper
منابع مشابه
MafB negatively regulates RANKL-mediated osteoclast differentiation.
Receptor activator of nuclear factor kappaB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors. Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation. Expression levels of MafB are significantly reduced by RANKL during osteoclastogenesis. Overexpression of MafB in bone marrow-derived monocyte/macro...
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